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KMID : 0603820130190030224
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 3 p.224 ~ p.232
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Cucurbitacin I, a Natural Cell?permeable Triterpenoid, Suppresses Colitis?associated Colon Carcinogenesis in Mice
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Kim Hyeon-Jin
Kim Jin-Kyung
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Abstract
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Cucurbitacins are a natural cell?permeable triterpenoid compound isolated from Cucurbitaceae and Cruciferae.
Cucurbitacins have been used as folk medicine because of their anti?inflammatory and analgesic effects. In the present
study, we investigate the anti?cancer effects of cucurbitacin I on colitis?associated colon carcinogenesis induced by
azoxymethane (AOM)/dextran sodium sulfate (DSS) in BALB/c mice. Cucurbitacin I treatment attenuated loss of body
weight and decreased the number of colon tumors. Western blot analysis showed that cucurbitacin I treatment significantly
inhibited the protein expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)?α and interleukin
(IL)?6. These results suggest that cucurbitacin I suppressed inflammatory reaction and tumor development in colitis?associated colon carcinogenesis.
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KEYWORD
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Cucurbitacin I, AOM/DSS, Colitis?associated colon carcinogenesis
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